The study of human diploid cells in vitro has established the identical values of parameters of proliferative potential in monozygotic twins and their significant difference in dizygotic twins ~ a decrease in the proliferative potential of cells obtained from patients with hereditary diseases, the principal phenotypic manifestations of which are signs of premature aging , and negative correlation between the proliferative potential of cells and the donor's age . These findings are evidence in support of genetically determined control over this parameter and ~he presence of correlation between the proliferative potential of cells in vitro and in vivo. The percentage of cells capable of forming colonies consisting of 16 cells or more is a reliable indicator of the proliferative potential of a strain . Of all strains studied in this respect only two are embryonic, and they have been obtained from lung tissue (strains Wi-38 and IMR-90). There are some doubts about the validity of comparing these strains with postnatal strains obtained from skin biopsy material . There is sufficient information in the literature on the character of proliferation of human fibroblasts in vitro in connection with a study of aging problems. Results obtained by the study of each group are often a~eraged, and for that reason there are no data on individual variation within each group of donors.
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